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In the United States, the primary regulatory body for medical biotech is the National Institutes of Health (NIH), which de nes itself as the steward of medical and behavioral research for the nation. The NIH, which is a com ponent of the U.S. Department of Health and Human Services, directs ac tivity in the medical biotech arena through grants and contracts in speci c areas. Like the World Health Organization, which also heavily in uences the medical biotech industry, NIH manipulates the biotech infrastructure through funding opportunities.

v'2 '

= iv'2 .

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Appendix A Your Rights as a Taxpayer Appendix B How to get Help With Unresolved Tax Problems Appendix C Protecting Taxpayer s Rights

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(5.31) The reason for the v'2 factor will become evident soon. For each of the two pairs ofreal variables (qr,Pr) and (qi,Pi) in (5.31), we have a pair of driven harmonic oscillator equations qr= - , and where (5.34) The equations of motion (5.32) and (5.33) can be obtained from a Hamiltonian such as (5.24). As they are all independent variables, the four equations of motion can be

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Much of the activity in military biotech is necessarily not available for pub lic scrutiny or policed by public policies. However, the National Institutes of Health works in concert with the Department of Defense to direct acad emic and commercial research through funding opportunities. For exam ple, the DOD and NIH have collaborated on smallpox vaccine development. The World Health Organization is also involved in the mili tary biotech arena, especially regarding the research and development of chemical and biochemical warfare agents.

The first part of this publication explains some of your most important rights as a taxpayer. The second part explains the examination, appeal, collection, and refund processes. This publication is also available in Spanish.

. qi Pi =-,

(5.32)

(Rev. August 2000)

(5.33)

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Chinese population and the political systems Today, traditional Chinese medicine is practiced alongside Western medicine in much of Asia Practi tioners use drugs from the West and traditional Chinese herbs and prac tices However, most physicians in the United States and Europe who are trained in Western medicine continue to avoid prescribing traditional Chi nese medicines Even though there are many medical traditions worldwide, the techno logical developments more directly relevant to the modern pharmaceutical industry are predominantly Western phenomena A prominent landmark for the scienti c basis of Western medicine is the invention of the multilens microscope by two Dutch spectacle makers, Zaccharias Janssen and his son Hans in 1590, which lead the way to the discovery of bacteria nearly a century later The discovery of protein in 1830 by the German physiologist Johannes Muller was essential to eventually understanding the role of genes in the body.

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You are responsible for paying only the correct amount of tax due under the law no more, no less. If you cannot pay all of your tax when it is due, you may be able to make monthly installment payments.

. 81i Pr = - 8qr'

(5.35)

Modern genetics owes its start to the Austrian monk Gregor Mendel who discovered the laws of genetic inheritance in 1863 Around the time of Mendel s work, the French physician Louis Pasteur developed sterilization ( pasteurization ), a process that was destined to profoundly improve public health The Swiss physician Friedrich Miescher s isolation of DNA in 1869 was a critical step toward our understanding that genes are com posed of DNA The German scientist and Nobel laureate Robert Koch dis covered that bacteria cause disease, and by doing so founded modern medical bacteriology in 1870 Throughout the remainder of the nineteenth century, German scientists developed the principles of organic chemistry, creating synthetic dyes, some of which had pharmaceutical properties For example, scientists at Bayer synthesized aspirin in 1885 as an alternative to the increasingly expensive bark of the white (Salix alba) and black (Salix nigra) willow.

The IRS will not disclose to anyone the information you give us, except as authorized by law. You have the right to know why we are asking you for information, how we will use it, and what happens if you do not provide requested information.

with the equations of motion given by 811. . qr = -8 ' Pr and (5.36)

(5.37)

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